Astrocytic pyruvate carboxylation: Status after 35 years
نویسندگان
چکیده
منابع مشابه
Decortication after 35 years.
A 66-year-old white woman had a paraffin plombage performed in 1940 for tuberculosis. In 1975, she had decortication for terminal respiratory insufficiency, with return to an active life. Thirty-five years of pulmonary compression does not produce irreversible changes in the pulmonary parenchyma.
متن کاملThe pentose phosphate pathway and pyruvate carboxylation after neonatal hypoxic-ischemic brain injury.
The neonatal brain is vulnerable to oxidative stress, and the pentose phosphate pathway (PPP) may be of particular importance to limit the injury. Furthermore, in the neonatal brain, neurons depend on de novo synthesis of neurotransmitters via pyruvate carboxylase (PC) in astrocytes to increase neurotransmitter pools. In the adult brain, PPP activity increases in response to various injuries wh...
متن کاملAcute hibernation decreases myocardial pyruvate carboxylation and citrate release.
In the well-perfused heart, pyruvate carboxylation accounts for 3-6% of the citric acid cycle (CAC) flux, and CAC carbon is lost via citrate release. We investigated the effects of an acute reduction in coronary flow on these processes and on the tissue content of CAC intermediates. Measurements were made in an open-chest anesthetized swine model. Left anterior descending coronary artery blood ...
متن کاملNeuronal pyruvate carboxylation supports formation of transmitter glutamate.
Release of transmitter glutamate implies a drain of alpha-ketoglutarate from neurons, because glutamate, which is formed from alpha-ketoglutarate, is taken up by astrocytes. It is generally believed that this drain is compensated by uptake of glutamine from astrocytes, because neurons are considered incapable of de novo synthesis of tricarboxylic acid cycle intermediates, which requires pyruvat...
متن کاملthree distinct urethral fistulae 35 years after pelvic radiation
introduction: while the development of fistulae is a well-known complication of radiotherapy, such fistulae can often be challenging to manage. case presentation: we describe the case of a 37 year old male who developed in succession a urethrocutaneous fistula to the thigh, a rectourethral fistula and a peritoneo-urethral fistula 35 years after radiotherapy for pediatric pelvic rhabdomyosarcoma...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Neuroscience Research
سال: 2019
ISSN: 0360-4012,1097-4547
DOI: 10.1002/jnr.24402